Depolarization increases PtdIns(4,5)P2 level and KCNQ currents through PI4 kinase mechanisms
نویسندگان
چکیده
Xuan Zhang, Xingjuan Chen, Caixia Jia, Xian Geng, Xiaona Du and Hailin Zhang Department of Pharmacology, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang, Hebei, 050017, China Running Title: Depolarization increases membrane PIP2 1 Contribute equally to this work. *Corresponding author: Hailin Zhang, Tel.: 86 0311 86265562; fax: 86 0311 86057291; E-mail: [email protected], [email protected]
منابع مشابه
Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation.
KCNQ2/3 currents are the molecular basis of the neuronal M currents that play a critical role in neuron excitability. Many neurotransmitters modulate M/KCNQ currents through their G-protein-coupled receptors. Membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation are two mechanisms that have been proposed for modulation of KCNQ2/3 currents. In this study, we studied regulation of KCNQ2/3...
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